Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2797160..2797755 Replicon chromosome
Accession NZ_CP113230
Organism Pseudomonas aeruginosa strain BIAI 160

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag OSZ60_RS13320 Protein ID WP_003113526.1
Coordinates 2797160..2797438 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OSZ60_RS13325 Protein ID WP_003099268.1
Coordinates 2797450..2797755 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ60_RS13300 (OSZ60_13300) 2792586..2793824 + 1239 WP_033938786.1 C69 family dipeptidase -
OSZ60_RS13305 (OSZ60_13305) 2793886..2794533 + 648 WP_003095021.1 carbonate dehydratase -
OSZ60_RS13310 (OSZ60_13310) 2794603..2796831 - 2229 WP_003099265.1 TonB-dependent receptor -
OSZ60_RS13315 (OSZ60_13315) 2796979..2797107 + 129 Protein_2630 integrase -
OSZ60_RS13320 (OSZ60_13320) 2797160..2797438 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSZ60_RS13325 (OSZ60_13325) 2797450..2797755 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
OSZ60_RS13335 (OSZ60_13335) 2798152..2799252 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
OSZ60_RS13340 (OSZ60_13340) 2799293..2799877 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
OSZ60_RS13345 (OSZ60_13345) 2799919..2800533 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
OSZ60_RS13350 (OSZ60_13350) 2800650..2801591 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
OSZ60_RS13360 (OSZ60_13360) 2801758..2802606 - 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T265630 WP_003113526.1 NZ_CP113230:2797160-2797438 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT265630 WP_003099268.1 NZ_CP113230:2797450-2797755 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References