Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2704323..2704999 Replicon chromosome
Accession NZ_CP113228
Organism Streptomyces albidoflavus strain J1074_D14

Toxin (Protein)


Gene name HigB2 Uniprot ID D6AZC1
Locus tag SAD14_RS11990 Protein ID WP_003949888.1
Coordinates 2704637..2704999 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SAD14_RS11985 Protein ID WP_015507386.1
Coordinates 2704323..2704640 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAD14_RS11960 (SAD14_2454) 2699609..2700670 + 1062 WP_008404846.1 hypothetical protein -
SAD14_RS11965 (SAD14_2455) 2700886..2701416 + 531 WP_003949893.1 toxin-antitoxin system HicB family antitoxin -
SAD14_RS11970 (SAD14_2456) 2701518..2702387 + 870 WP_003949892.1 DUF4097 family beta strand repeat-containing protein -
SAD14_RS11975 (SAD14_2457) 2702491..2703465 + 975 WP_003949891.1 daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein -
SAD14_RS11980 (SAD14_2458) 2703462..2704244 + 783 WP_003949890.1 ABC transporter permease -
SAD14_RS11985 (SAD14_2459) 2704323..2704640 - 318 WP_015507386.1 helix-turn-helix transcriptional regulator Antitoxin
SAD14_RS11990 2704637..2704999 - 363 WP_003949888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SAD14_RS11995 (SAD14_2461) 2704998..2706695 + 1698 WP_003949889.1 hypothetical protein -
SAD14_RS12000 (SAD14_2462) 2706785..2707027 - 243 WP_015507388.1 hypothetical protein -
SAD14_RS12005 (SAD14_2463) 2707331..2708185 + 855 WP_015507389.1 STAS domain-containing protein -
SAD14_RS12010 (SAD14_2464) 2708182..2708562 + 381 WP_003949885.1 STAS domain-containing protein -
SAD14_RS12015 (SAD14_2465) 2708562..2708978 + 417 WP_003949884.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13472.34 Da        Isoelectric Point: 4.7680

>T265627 WP_003949888.1 NZ_CP113228:c2704999-2704637 [Streptomyces albidoflavus]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQRTEWYQEAIPLAEQRYALYLKEREREEGGRP

Download         Length: 363 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11572.07 Da        Isoelectric Point: 9.8236

>AT265627 WP_015507386.1 NZ_CP113228:c2704640-2704323 [Streptomyces albidoflavus]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRISQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y6SI38

Antitoxin

Source ID Structure

References