Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3927909..3928506 Replicon chromosome
Accession NZ_CP113216
Organism Klebsiella pneumoniae strain SCLC9-2

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag OT489_RS19575 Protein ID WP_004893639.1
Coordinates 3928189..3928506 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag OT489_RS19570 Protein ID WP_004142561.1
Coordinates 3927909..3928196 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT489_RS19540 (3924116) 3924116..3924364 + 249 WP_002893037.1 DUF1158 domain-containing protein -
OT489_RS19545 (3924382) 3924382..3924723 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OT489_RS19550 (3924754) 3924754..3925869 - 1116 WP_074180844.1 MBL fold metallo-hydrolase -
OT489_RS19555 (3926049) 3926049..3926630 + 582 WP_100757106.1 TetR/AcrR family transcriptional regulator -
OT489_RS19560 (3926630) 3926630..3926998 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
OT489_RS19565 (3927118) 3927118..3927771 + 654 Protein_3836 oxygen-insensitive NAD(P)H nitroreductase -
OT489_RS19570 (3927909) 3927909..3928196 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
OT489_RS19575 (3928189) 3928189..3928506 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT489_RS19580 (3928691) 3928691..3929734 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
OT489_RS19585 (3930404) 3930404..3931270 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
OT489_RS19590 (3931379) 3931379..3932806 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T265616 WP_004893639.1 NZ_CP113216:c3928506-3928189 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT265616 WP_004142561.1 NZ_CP113216:c3928196-3927909 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References