Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 353314..353960 Replicon chromosome
Accession NZ_CP113216
Organism Klebsiella pneumoniae strain SCLC9-2

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag OT489_RS01625 Protein ID WP_004188313.1
Coordinates 353314..353661 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag OT489_RS01630 Protein ID WP_004188315.1
Coordinates 353661..353960 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT489_RS01615 (349240) 349240..350673 + 1434 WP_002920564.1 glycogen synthase GlgA -
OT489_RS01620 (350691) 350691..353138 + 2448 WP_002920561.1 glycogen phosphorylase -
OT489_RS01625 (353314) 353314..353661 + 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OT489_RS01630 (353661) 353661..353960 + 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
OT489_RS01635 (354023) 354023..355531 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
OT489_RS01640 (355736) 355736..356065 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
OT489_RS01645 (356116) 356116..356946 + 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
OT489_RS01650 (356996) 356996..357754 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T265608 WP_004188313.1 NZ_CP113216:353314-353661 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT265608 WP_004188315.1 NZ_CP113216:353661-353960 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References