Detailed information of TA system TA026557

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2113287..2113586
• Replicon: chromosome
• Accession: NC_017331
• Organism: Staphylococcus aureus subsp. aureus TW20

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: SATW20_RS16435
• Protein ID: WP_072482930.1
• Coordinates: 2113410..2113586 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2113287..2113342 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SATW20_RS10670	2108845..2109024	+	180	WP_000669789.1	hypothetical protein	-
SATW20_RS10680	2109335..2109595	+	261	WP_001791826.1	hypothetical protein	-
SATW20_RS10685	2109648..2109998	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
SATW20_RS16825	2110508..2110843	-	336	Protein_2030	SH3 domain-containing protein	-
SATW20_RS10695	2111495..2111986	-	492	WP_000920041.1	staphylokinase	-
SATW20_RS10700	2112177..2112932	-	756	WP_000861038.1	CHAP domain-containing protein	-
SATW20_RS10705	2112944..2113198	-	255	WP_000611512.1	phage holin	-
SATW20_RS10710	2113250..2113357	+	108	Protein_2034	hypothetical protein	-
-	2113279..2113418	+	140	NuclAT_0	-	-
-	2113279..2113418	+	140	NuclAT_0	-	-
-	2113279..2113418	+	140	NuclAT_0	-	-
-	2113279..2113418	+	140	NuclAT_0	-	-
-	2113287..2113342	+	56	-	-	Antitoxin
SATW20_RS16435	2113410..2113586	-	177	WP_072482930.1	putative holin-like toxin	Toxin
SATW20_RS10720	2113695..2114468	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SATW20_RS10725	2114841..2115215	-	375	WP_000340977.1	hypothetical protein	-
SATW20_RS10730	2115271..2115558	-	288	WP_001262621.1	hypothetical protein	-
SATW20_RS10735	2115604..2115756	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2109648..2167173	57525

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T26557 WP_072482930.1 NC_017331:c2113586-2113410 [Staphylococcus aureus subsp. aureus TW20]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T26557 NC_017331:c2113586-2113410 [Staphylococcus aureus subsp. aureus TW20]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT26557 NC_017331:2113287-2113342 [Staphylococcus aureus subsp. aureus TW20]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin