Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 762139..762914 Replicon chromosome
Accession NZ_CP113173
Organism Klebsiella pneumoniae strain TSYCC10-2

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag OT486_RS03840 Protein ID WP_004150910.1
Coordinates 762429..762914 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag OT486_RS03835 Protein ID WP_004150912.1
Coordinates 762139..762432 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OT486_RS03815 (757347) 757347..757949 - 603 WP_002916735.1 short chain dehydrogenase -
OT486_RS03820 (758047) 758047..758958 + 912 WP_004188550.1 LysR family transcriptional regulator -
OT486_RS03825 (758959) 758959..760107 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
OT486_RS03830 (760118) 760118..761494 - 1377 WP_004217775.1 cystathionine beta-synthase -
OT486_RS03835 (762139) 762139..762432 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
OT486_RS03840 (762429) 762429..762914 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
OT486_RS03845 (763618) 763618..764211 + 594 WP_004188553.1 hypothetical protein -
OT486_RS03850 (764308) 764308..764524 + 217 Protein_757 transposase -
OT486_RS03855 (765130) 765130..766002 + 873 WP_004188557.1 ParA family protein -
OT486_RS03860 (766002) 766002..766385 + 384 WP_004150906.1 hypothetical protein -
OT486_RS03865 (766378) 766378..767745 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 764308..764460 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T265483 WP_004150910.1 NZ_CP113173:762429-762914 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT265483 WP_004150912.1 NZ_CP113173:762139-762432 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References