Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 88326..89053 | Replicon | plasmid pTSNTC10-1_tmex_202k |
| Accession | NZ_CP113166 | ||
| Organism | Klebsiella pneumoniae strain TSNTC10-1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | OT484_RS27395 | Protein ID | WP_011251285.1 |
| Coordinates | 88326..88637 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | OT484_RS27400 | Protein ID | WP_011251286.1 |
| Coordinates | 88634..89053 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OT484_RS27370 (OT484_27370) | 85092..85271 | - | 180 | Protein_89 | IS5/IS1182 family transposase | - |
| OT484_RS27375 (OT484_27375) | 85311..86839 | - | 1529 | Protein_90 | IS66 family transposase | - |
| OT484_RS27380 (OT484_27380) | 86888..87235 | - | 348 | WP_004114612.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| OT484_RS27385 (OT484_27385) | 87232..87570 | - | 339 | WP_023288266.1 | transposase | - |
| OT484_RS27390 (OT484_27390) | 87684..88121 | + | 438 | Protein_93 | DDE-type integrase/transposase/recombinase | - |
| OT484_RS27395 (OT484_27395) | 88326..88637 | + | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| OT484_RS27400 (OT484_27400) | 88634..89053 | + | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| OT484_RS27405 (OT484_27405) | 89200..90168 | + | 969 | WP_077268729.1 | IS5 family transposase | - |
| OT484_RS27410 (OT484_27410) | 90237..90772 | - | 536 | Protein_97 | transposase | - |
| OT484_RS27415 (OT484_27415) | 91297..92664 | - | 1368 | WP_032437385.1 | formimidoylglutamate deiminase | - |
| OT484_RS27420 (OT484_27420) | 92767..93528 | + | 762 | WP_017900871.1 | histidine utilization repressor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul1 / blaDHA-1 / qnrB4 / tet(A) / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr / aac(3)-IId / mph(A) / qnrB91 | - | 1..202189 | 202189 | |
| - | inside | IScluster/Tn | - | - | 80402..90168 | 9766 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T265461 WP_011251285.1 NZ_CP113166:88326-88637 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT265461 WP_011251286.1 NZ_CP113166:88634-89053 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|