265441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3421041..3421801 Replicon chromosome
Accession NZ_CP113163
Organism Citrobacter braakii strain LBA3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MKJ05_RS16310 Protein ID WP_114683723.1
Coordinates 3421041..3421352 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MKJ05_RS16315 Protein ID WP_114683722.1
Coordinates 3421349..3421801 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKJ05_RS16280 (MKJ05_16280) 3416708..3417610 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
MKJ05_RS16285 (MKJ05_16285) 3417607..3418242 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
MKJ05_RS16290 (MKJ05_16290) 3418239..3419168 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
MKJ05_RS16295 (MKJ05_16295) 3419205..3419579 - 375 WP_016155182.1 type II toxin-antitoxin system VapC family toxin -
MKJ05_RS16300 (MKJ05_16300) 3419579..3419821 - 243 WP_181818053.1 CopG family transcriptional regulator -
MKJ05_RS16305 (MKJ05_16305) 3420027..3420956 + 930 WP_267583561.1 alpha/beta hydrolase -
MKJ05_RS16310 (MKJ05_16310) 3421041..3421352 + 312 WP_114683723.1 type II toxin-antitoxin system HigB family toxin Toxin
MKJ05_RS16315 (MKJ05_16315) 3421349..3421801 + 453 WP_114683722.1 helix-turn-helix domain-containing protein Antitoxin
MKJ05_RS16320 (MKJ05_16320) 3421819..3422760 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
MKJ05_RS16325 (MKJ05_16325) 3422805..3423242 - 438 WP_003028671.1 D-aminoacyl-tRNA deacylase -
MKJ05_RS16330 (MKJ05_16330) 3423239..3424111 - 873 WP_114683721.1 virulence factor BrkB family protein -
MKJ05_RS16335 (MKJ05_16335) 3424105..3424704 - 600 WP_114683720.1 glucose-1-phosphatase -
MKJ05_RS16340 (MKJ05_16340) 3424809..3425612 - 804 WP_016155173.1 DeoR/GlpR family DNA-binding transcription regulator -
MKJ05_RS16345 (MKJ05_16345) 3425646..3426542 - 897 WP_019077939.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(95-148)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12498.62 Da        Isoelectric Point: 10.0209

>T265441 WP_114683723.1 NZ_CP113163:3421041-3421352 [Citrobacter braakii]
VHVISRKPFNEAILRFPNHMAALVDLLNILERKMFHTPEEMKQYIPSLDNFKYRNKWWVINVSGNCLRLIAYIDFKLQKV
FVKHIVHHAEYDRLTTYYRGHKE

Download         Length: 312 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16969.30 Da        Isoelectric Point: 5.2636

>AT265441 WP_114683722.1 NZ_CP113163:3421349-3421801 [Citrobacter braakii]
MRTHESHQIDTASVELMIDTFTDAVKKIPLLGKEQNEAEYRKALALVEFLVDRDDLENPLFELLSARIRDYEKHAPEFSA
LNQQLEHTPHGVALLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVSHIKMLAERFNLPADAFIE

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References