Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 21057..21652 Replicon chromosome
Accession NZ_CP113106
Organism Pseudomonas aeruginosa strain BIAI 157

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag OSZ59_RS00095 Protein ID WP_003113526.1
Coordinates 21057..21335 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OSZ59_RS00100 Protein ID WP_003099268.1
Coordinates 21347..21652 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ59_RS00075 (OSZ59_00075) 16483..17721 + 1239 WP_033938786.1 C69 family dipeptidase -
OSZ59_RS00080 (OSZ59_00080) 17783..18430 + 648 WP_003095021.1 carbonate dehydratase -
OSZ59_RS00085 (OSZ59_00085) 18500..20728 - 2229 WP_003099265.1 TonB-dependent receptor -
OSZ59_RS00090 (OSZ59_00090) 20876..21004 + 129 Protein_17 integrase -
OSZ59_RS00095 (OSZ59_00095) 21057..21335 + 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSZ59_RS00100 (OSZ59_00100) 21347..21652 + 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
OSZ59_RS00110 (OSZ59_00110) 22049..23149 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
OSZ59_RS00115 (OSZ59_00115) 23190..23774 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
OSZ59_RS00120 (OSZ59_00120) 23816..24430 - 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
OSZ59_RS00125 (OSZ59_00125) 24547..25488 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
OSZ59_RS00135 (OSZ59_00135) 25655..26503 - 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T265419 WP_003113526.1 NZ_CP113106:21057-21335 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT265419 WP_003099268.1 NZ_CP113106:21347-21652 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References