Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 2695435..2695773 Replicon chromosome
Accession NZ_CP113105
Organism Staphylococcus aureus strain BIAI 117

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OSZ56_RS13260 Protein ID WP_011447039.1
Coordinates 2695435..2695611 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 2695599..2695773 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ56_RS13240 2690670..2694455 + 3786 WP_075111493.1 phage tail spike protein -
OSZ56_RS13245 2694445..2694597 + 153 WP_001153681.1 hypothetical protein -
OSZ56_RS13250 2694644..2694931 + 288 WP_001040261.1 hypothetical protein -
OSZ56_RS13255 2694989..2695285 + 297 WP_000539688.1 DUF2951 domain-containing protein -
OSZ56_RS13260 2695435..2695611 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 2695599..2695773 - 175 - - Antitoxin
OSZ56_RS13270 2695823..2696077 + 255 WP_000611512.1 phage holin -
OSZ56_RS13275 2696089..2696844 + 756 WP_000861038.1 CHAP domain-containing protein -
OSZ56_RS13280 2697034..2697525 + 492 WP_000920041.1 staphylokinase -
OSZ56_RS13285 2698126..2698460 + 335 Protein_2575 SH3 domain-containing protein -
OSZ56_RS13290 2698555..2699004 - 450 WP_000727645.1 chemotaxis-inhibiting protein CHIPS -
OSZ56_RS13295 2699687..2700037 + 351 WP_000702262.1 complement inhibitor SCIN-A -
OSZ56_RS13300 2700090..2700350 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 2633249..2700037 66788


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-58)


Sequences


Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T265415 WP_011447039.1 NZ_CP113105:2695435-2695611 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp


Antitoxin


Download         Length: 175 bp

>AT265415 NZ_CP113105:c2695773-2695599 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7NS1


Antitoxin

Download structure file

References