265409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2246827..2247344 Replicon chromosome
Accession NZ_CP113105
Organism Staphylococcus aureus strain BIAI 117

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag OSZ56_RS10820 Protein ID WP_000251928.1
Coordinates 2247078..2247344 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag OSZ56_RS10815 Protein ID WP_000584497.1
Coordinates 2246827..2247078 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ56_RS10780 (2242169) 2242169..2242900 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
OSZ56_RS10785 (2242997) 2242997..2243509 - 513 Protein_2089 FemA/FemB family glycyltransferase FmhA -
OSZ56_RS10790 (2243622) 2243622..2244569 + 948 WP_000121211.1 IS30-like element ISSau1 family transposase -
OSZ56_RS10795 (2244578) 2244578..2245321 - 744 Protein_2091 FemA/FemB family glycyltransferase FmhA -
OSZ56_RS10800 (2245576) 2245576..2245938 + 363 WP_000819843.1 DUF4467 domain-containing protein -
OSZ56_RS10805 (2245957) 2245957..2246556 + 600 WP_267810267.1 DsbA family protein -
OSZ56_RS10810 (2246563) 2246563..2246663 + 101 Protein_2094 hypothetical protein -
OSZ56_RS10815 (2246827) 2246827..2247078 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OSZ56_RS10820 (2247078) 2247078..2247344 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
OSZ56_RS10825 (2247637) 2247637..2249184 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OSZ56_RS10830 (2249370) 2249370..2249837 + 468 WP_000153340.1 SRPBCC domain-containing protein -
OSZ56_RS10835 (2249924) 2249924..2250106 + 183 WP_000079140.1 hypothetical protein -
OSZ56_RS10840 (2250309) 2250309..2251133 + 825 WP_000594640.1 formate/nitrite transporter family protein -
OSZ56_RS10845 (2251601) 2251601..2252137 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2243622..2244569 947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T265409 WP_000251928.1 NZ_CP113105:2247078-2247344 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT265409 WP_000584497.1 NZ_CP113105:2246827-2247078 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References