265407

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2189199..2189722 Replicon chromosome
Accession NZ_CP113105
Organism Staphylococcus aureus strain BIAI 117

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag OSZ56_RS10535 Protein ID WP_000074047.1
Coordinates 2189456..2189722 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag OSZ56_RS10530 Protein ID WP_000587617.1
Coordinates 2189199..2189456 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSZ56_RS10510 (2184277) 2184277..2185470 + 1194 WP_000675407.1 MFS transporter -
OSZ56_RS10515 (2185694) 2185694..2186443 - 750 WP_000072447.1 CPBP family lipoprotein N-acylation protein LnsB -
OSZ56_RS10520 (2186639) 2186639..2188216 + 1578 WP_267810241.1 FMN-binding glutamate synthase family protein -
OSZ56_RS10525 (2188384) 2188384..2188839 - 456 WP_000732090.1 YehR family lipoprotein -
OSZ56_RS10530 (2189199) 2189199..2189456 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OSZ56_RS10535 (2189456) 2189456..2189722 + 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
OSZ56_RS10540 (2190078) 2190078..2191154 + 1077 WP_001076679.1 M42 family metallopeptidase -
OSZ56_RS10545 (2191500) 2191500..2192162 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
OSZ56_RS10550 (2192155) 2192155..2192931 + 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
OSZ56_RS10555 (2193325) 2193325..2194512 + 1188 WP_000026190.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T265407 WP_000074047.1 NZ_CP113105:2189456-2189722 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT265407 WP_000587617.1 NZ_CP113105:2189199-2189456 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References