Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3957997..3958673 Replicon chromosome
Accession NZ_CP113103
Organism Streptomyces sp. NA13

Toxin (Protein)


Gene name HigB2 Uniprot ID D6AZC1
Locus tag OSU72_RS17270 Protein ID WP_003949888.1
Coordinates 3957997..3958359 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OSU72_RS17275 Protein ID WP_018471255.1
Coordinates 3958356..3958673 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSU72_RS17240 (OSU72_17240) 3953283..3954353 - 1071 WP_267813570.1 ATP-binding protein/SpoIIE family protein phosphatase -
OSU72_RS17245 (OSU72_17245) 3954350..3954766 - 417 WP_003949884.1 ATP-binding protein -
OSU72_RS17250 (OSU72_17250) 3954766..3955146 - 381 WP_003949885.1 STAS domain-containing protein -
OSU72_RS17255 (OSU72_17255) 3955143..3955997 - 855 WP_018893839.1 STAS domain-containing protein -
OSU72_RS17260 (OSU72_17260) 3956301..3956543 + 243 WP_037844511.1 hypothetical protein -
OSU72_RS17265 (OSU72_17265) 3956721..3957998 - 1278 WP_267812553.1 hypothetical protein -
OSU72_RS17270 (OSU72_17270) 3957997..3958359 + 363 WP_003949888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSU72_RS17275 (OSU72_17275) 3958356..3958673 + 318 WP_018471255.1 helix-turn-helix transcriptional regulator Antitoxin
OSU72_RS17280 (OSU72_17280) 3958752..3959534 - 783 WP_003949890.1 ABC transporter permease -
OSU72_RS17285 (OSU72_17285) 3959531..3960505 - 975 WP_267813571.1 ATP-binding cassette domain-containing protein -
OSU72_RS17290 (OSU72_17290) 3960609..3961478 - 870 WP_267812555.1 DUF4097 family beta strand repeat-containing protein -
OSU72_RS17295 (OSU72_17295) 3961580..3962110 - 531 WP_003949893.1 toxin-antitoxin system HicB family antitoxin -
OSU72_RS17300 (OSU72_17300) 3962316..3963377 - 1062 WP_267812556.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13472.34 Da        Isoelectric Point: 4.7680

>T265404 WP_003949888.1 NZ_CP113103:3957997-3958359 [Streptomyces sp. NA13]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQRTEWYQEAIPLAEQRYALYLKEREREEGGRP

Download         Length: 363 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11558.05 Da        Isoelectric Point: 9.8236

>AT265404 WP_018471255.1 NZ_CP113103:3958356-3958673 [Streptomyces sp. NA13]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRVSQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y6SI38

Antitoxin

Source ID Structure

References