Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2538403..2539133 Replicon chromosome
Accession NZ_CP113085
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OSE17_RS11450 Protein ID WP_163851839.1
Coordinates 2538816..2539133 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OSE17_RS11445 Protein ID WP_010258577.1
Coordinates 2538403..2538735 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS11425 (OSE17_11425) 2533781..2534422 + 642 WP_003849160.1 protein phosphatase CheZ -
OSE17_RS11430 (OSE17_11430) 2534611..2535762 + 1152 WP_010258565.1 flagellar biosynthesis protein FlhB -
OSE17_RS11435 (OSE17_11435) 2535755..2537848 + 2094 WP_010258569.1 flagellar biosynthesis protein FlhA -
OSE17_RS11440 (OSE17_11440) 2537848..2538240 + 393 WP_172608759.1 flagellar protein FlhE -
OSE17_RS11445 (OSE17_11445) 2538403..2538735 - 333 WP_010258577.1 HigA family addiction module antitoxin Antitoxin
OSE17_RS11450 (OSE17_11450) 2538816..2539133 - 318 WP_163851839.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSE17_RS11455 (OSE17_11455) 2539208..2540206 - 999 WP_172608757.1 aldo/keto reductase -
OSE17_RS11460 (OSE17_11460) 2540419..2541354 - 936 WP_172608756.1 LysR family transcriptional regulator -
OSE17_RS11465 (OSE17_11465) 2541442..2543172 - 1731 WP_010258588.1 arginine--tRNA ligase -
OSE17_RS11470 (OSE17_11470) 2543383..2543505 - 123 WP_009089698.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12311.17 Da        Isoelectric Point: 10.2104

>T265378 WP_163851839.1 NZ_CP113085:c2539133-2538816 [Pantoea agglomerans]
VATLRNIESFRDDWLKDYFLYGKFSKRIPSSLSSALARKLDIINAAISYKDLKSPPGNRYEELNPPLKGYASIRVNEQYR
LIFKWIEGKAVDLYLDAHSYKKHKR

Download         Length: 318 bp

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12615.48 Da        Isoelectric Point: 5.1473

>AT265378 WP_010258577.1 NZ_CP113085:c2538735-2538403 [Pantoea agglomerans]
MNQATRKPTTVGDVLLYEYLEPTGLKILDLAEMLKVHRNTVSALVNNNRKLTPDMAFRLAAAFETSVEFWLNLQNSVDIW
EVMHDARAQEEISRVTPLKDFLVQKENQLA

Download         Length: 333 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References