Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2356688..2357348 Replicon chromosome
Accession NZ_CP113085
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name higB Uniprot ID A0A349IFT5
Locus tag OSE17_RS10610 Protein ID WP_010670918.1
Coordinates 2356688..2357041 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OSE17_RS10615 Protein ID WP_172608024.1
Coordinates 2357046..2357348 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS10590 (OSE17_10590) 2351885..2352166 + 282 WP_010247933.1 hypothetical protein -
OSE17_RS10595 (OSE17_10595) 2352265..2352666 + 402 WP_010247930.1 cell envelope integrity TolA C-terminal domain-containing protein -
OSE17_RS10600 (OSE17_10600) 2352743..2354905 - 2163 WP_172608023.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
OSE17_RS10605 (OSE17_10605) 2355301..2356389 + 1089 WP_029519393.1 YncE family protein -
OSE17_RS10610 (OSE17_10610) 2356688..2357041 + 354 WP_010670918.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSE17_RS10615 (OSE17_10615) 2357046..2357348 + 303 WP_172608024.1 XRE family transcriptional regulator Antitoxin
OSE17_RS10625 (OSE17_10625) 2358020..2358943 + 924 WP_031591254.1 sugar ABC transporter substrate-binding protein -
OSE17_RS10630 (OSE17_10630) 2358976..2360459 + 1484 Protein_2047 sugar ABC transporter ATP-binding protein -
OSE17_RS10635 (OSE17_10635) 2360483..2361508 + 1026 WP_267713243.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13649.71 Da        Isoelectric Point: 8.4949

>T265377 WP_010670918.1 NZ_CP113085:2356688-2357041 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAALMVLREKGPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYQEMLPVADREFTHWLNSFKDEE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10989.81 Da        Isoelectric Point: 6.4707

>AT265377 WP_172608024.1 NZ_CP113085:2357046-2357348 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATYILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A349IFT5

Antitoxin

Source ID Structure

References