265376

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2330472..2331802 Replicon chromosome
Accession NZ_CP113085
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag OSE17_RS10485 Protein ID WP_267712442.1
Coordinates 2330472..2331494 (-) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A7X2SVD5
Locus tag OSE17_RS10490 Protein ID WP_010670935.1
Coordinates 2331491..2331802 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS10470 (OSE17_10470) 2326599..2327621 + 1023 WP_010247994.1 LLM class flavin-dependent oxidoreductase -
OSE17_RS10475 (OSE17_10475) 2327737..2327940 + 204 Protein_2018 hypothetical protein -
OSE17_RS10480 (OSE17_10480) 2328128..2330347 + 2220 WP_222939431.1 catalase/peroxidase HPI -
OSE17_RS10485 (OSE17_10485) 2330472..2331494 - 1023 WP_267712442.1 HipA domain-containing protein Toxin
OSE17_RS10490 (OSE17_10490) 2331491..2331802 - 312 WP_010670935.1 HipA N-terminal domain-containing protein Antitoxin
OSE17_RS10495 (OSE17_10495) 2331787..2332131 - 345 WP_010247978.1 helix-turn-helix transcriptional regulator -
OSE17_RS10505 (OSE17_10505) 2332909..2334030 + 1122 WP_172608013.1 Gfo/Idh/MocA family oxidoreductase -
OSE17_RS10510 (OSE17_10510) 2334121..2334951 - 831 WP_172608014.1 glycosyltransferase family 8 protein -
OSE17_RS10515 (OSE17_10515) 2334964..2336346 - 1383 WP_172608015.1 D-arabinono-1,4-lactone oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-300)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38581.18 Da        Isoelectric Point: 6.8346

>T265376 WP_267712442.1 NZ_CP113085:c2331494-2330472 [Pantoea agglomerans]
MNSERCLITLKRLKESELKTGYSTKGIRHLLGSLNVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLAKGELVVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFDVPPFGLMPFRHDENRPEELAFVIKRYDRTASDNARLHQEQLDGAMG
LGDKYGRIDNHKAISYEKAAKFLNTRVNSSLKSKRDLFLRIVYAYVLGNNDFHLRNIGIILPPQGSPWLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAGNAPGMNSEYGEYLGADFILLTQGMDINPTLARKWLSEVVSHHQLIIDTYNESHMPESQ
REAVLDYVARRITLLAVTEI

Download         Length: 1023 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11668.44 Da        Isoelectric Point: 4.7953

>AT265376 WP_010670935.1 NZ_CP113085:c2331802-2331491 [Pantoea agglomerans]
MARKIEVWLYNTLAGTLSEGQNGYTFCYLPTYAGCAISLSMPVRPEPYLSEELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMENGNDLLGAVVFKEITS

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7X2SVD5

References