Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 507158..507810 Replicon chromosome
Accession NZ_CP113085
Organism Pantoea agglomerans strain AB378

Toxin (Protein)


Gene name higB Uniprot ID A0A8X8DRT2
Locus tag OSE17_RS02240 Protein ID WP_010672045.1
Coordinates 507158..507511 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8X8DRN0
Locus tag OSE17_RS02245 Protein ID WP_010252120.1
Coordinates 507511..507810 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OSE17_RS02225 (OSE17_02225) 502884..504668 - 1785 WP_172608722.1 GMC family oxidoreductase -
OSE17_RS02230 (OSE17_02230) 504671..505405 - 735 WP_010672043.1 gluconate 2-dehydrogenase subunit 3 family protein -
OSE17_RS02235 (OSE17_02235) 505682..506923 + 1242 WP_033770848.1 peptide antibiotic transporter SbmA -
OSE17_RS02240 (OSE17_02240) 507158..507511 + 354 WP_010672045.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OSE17_RS02245 (OSE17_02245) 507511..507810 + 300 WP_010252120.1 XRE family transcriptional regulator Antitoxin
OSE17_RS02250 (OSE17_02250) 507933..508985 - 1053 WP_010672046.1 YncE family protein -
OSE17_RS02255 (OSE17_02255) 509188..509397 - 210 WP_009092571.1 DUF1471 domain-containing protein -
OSE17_RS02260 (OSE17_02260) 509610..510797 - 1188 WP_158149645.1 MFS transporter -
OSE17_RS02265 (OSE17_02265) 510902..511867 + 966 WP_267712858.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13660.67 Da        Isoelectric Point: 7.9792

>T265375 WP_010672045.1 NZ_CP113085:507158-507511 [Pantoea agglomerans]
MWTVLLSPRFESWLSEQEEALQEKMLADLGKLKVYGPDLPRPYADTLKGSQYRNMKELRVQFSGKPIRAFYAFDPVRQAI
VLCAGDKSHDKRFYIRMIRIADDEFSAWLAEQEKGNN

Download         Length: 354 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11116.99 Da        Isoelectric Point: 6.3781

>AT265375 WP_010252120.1 NZ_CP113085:507511-507810 [Pantoea agglomerans]
MRTLDDVIADFSPESQARIKKMSDEMILEVGLQMIREELQLSQKTLAEAMGVRQPAVAQIEQRGNEIKVATLKRYVEAMG
GKLSLDVELPTGKRVAFRI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References