Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 649938..650461 Replicon chromosome
Accession NZ_CP113052
Organism Staphylococcus aureus strain Fizz

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS084_RS03620 Protein ID WP_000074048.1
Coordinates 649938..650204 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS084_RS03625 Protein ID WP_000587616.1
Coordinates 650204..650461 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS084_RS03600 (645245) 645245..646432 - 1188 WP_000026194.1 MFS transporter -
OS084_RS03605 (646828) 646828..647604 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS084_RS03610 (647597) 647597..648259 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS084_RS03615 (648507) 648507..649583 - 1077 WP_001076671.1 M42 family metallopeptidase -
OS084_RS03620 (649938) 649938..650204 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS084_RS03625 (650204) 650204..650461 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS084_RS03630 (650567) 650567..650758 - 192 WP_223223607.1 hypothetical protein -
OS084_RS03635 (650820) 650820..651275 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OS084_RS03640 (651443) 651443..653020 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS084_RS03645 (653215) 653215..653964 + 750 WP_267838012.1 CPBP family lipoprotein N-acylation protein LnsB -
OS084_RS03650 (654188) 654188..655381 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265348 WP_000074048.1 NZ_CP113052:c650204-649938 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265348 WP_000587616.1 NZ_CP113052:c650461-650204 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References