Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 593090..593607 Replicon chromosome
Accession NZ_CP113052
Organism Staphylococcus aureus strain Fizz

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS084_RS03345 Protein ID WP_000113262.1
Coordinates 593090..593356 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag OS084_RS03350 Protein ID WP_000584502.1
Coordinates 593356..593607 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS084_RS03315 (588516) 588516..589052 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS084_RS03320 (589285) 589285..590109 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS084_RS03325 (590326) 590326..590508 - 183 WP_000230294.1 hypothetical protein -
OS084_RS03330 (590592) 590592..591059 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS084_RS03335 (591245) 591245..592795 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS084_RS03340 (592984) 592984..593055 - 72 Protein_614 hypothetical protein -
OS084_RS03345 (593090) 593090..593356 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS084_RS03350 (593356) 593356..593607 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS084_RS03355 (593772) 593772..593873 - 102 WP_001791744.1 hypothetical protein -
OS084_RS03360 (593880) 593880..594479 - 600 WP_000162813.1 DsbA family protein -
OS084_RS03365 (594498) 594498..594857 - 360 WP_000819847.1 DUF4467 domain-containing protein -
OS084_RS03370 (595112) 595112..596362 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS084_RS03375 (596459) 596459..597190 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS084_RS03380 (597187) 597187..597906 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265346 WP_000113262.1 NZ_CP113052:c593356-593090 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT265346 WP_000584502.1 NZ_CP113052:c593607-593356 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References