Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2099723..2100240 Replicon chromosome
Accession NZ_CP113051
Organism Staphylococcus aureus strain Viktor

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS088_RS10835 Protein ID WP_000113262.1
Coordinates 2099723..2099989 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS088_RS10840 Protein ID WP_000584499.1
Coordinates 2099989..2100240 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS088_RS10805 (2095160) 2095160..2095696 - 537 WP_154284075.1 GNAT family N-acetyltransferase -
OS088_RS10810 (2095930) 2095930..2096754 - 825 WP_000594640.1 formate/nitrite transporter family protein -
OS088_RS10815 (2096957) 2096957..2097139 - 183 WP_267814136.1 hypothetical protein -
OS088_RS10820 (2097226) 2097226..2097693 - 468 WP_000153345.1 SRPBCC domain-containing protein -
OS088_RS10825 (2097879) 2097879..2099429 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS088_RS10830 (2099617) 2099617..2099688 - 72 WP_223200558.1 hypothetical protein -
OS088_RS10835 (2099723) 2099723..2099989 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS088_RS10840 (2099989) 2099989..2100240 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS088_RS10845 (2100403) 2100403..2100504 - 102 Protein_2091 hypothetical protein -
OS088_RS10850 (2100511) 2100511..2101110 - 600 WP_154284074.1 DsbA family protein -
OS088_RS10855 (2101129) 2101129..2101491 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS088_RS10860 (2101746) 2101746..2102996 + 1251 WP_154284073.1 FemA/FemB family glycyltransferase FmhA -
OS088_RS10865 (2103093) 2103093..2103824 - 732 WP_154284072.1 amino acid ABC transporter ATP-binding protein -
OS088_RS10870 (2103821) 2103821..2104540 - 720 WP_154284071.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265336 WP_000113262.1 NZ_CP113051:c2099989-2099723 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265336 WP_000584499.1 NZ_CP113051:c2100240-2099989 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References