265317

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2327427..2327944 Replicon chromosome
Accession NZ_CP113049
Organism Staphylococcus aureus strain Ahri

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag OS089_RS11345 Protein ID WP_000113263.1
Coordinates 2327678..2327944 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS089_RS11340 Protein ID WP_000584499.1
Coordinates 2327427..2327678 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS089_RS11310 (2323127) 2323127..2323846 + 720 WP_000479576.1 amino acid ABC transporter permease -
OS089_RS11315 (2323843) 2323843..2324574 + 732 WP_000615464.1 amino acid ABC transporter ATP-binding protein -
OS089_RS11320 (2324671) 2324671..2325921 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
OS089_RS11325 (2326176) 2326176..2326538 + 363 WP_000819839.1 DUF4467 domain-containing protein -
OS089_RS11330 (2326557) 2326557..2327156 + 600 WP_000162810.1 DsbA family protein -
OS089_RS11335 (2327163) 2327163..2327254 + 92 Protein_2237 hypothetical protein -
OS089_RS11340 (2327427) 2327427..2327678 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS089_RS11345 (2327678) 2327678..2327944 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
OS089_RS11350 (2327979) 2327979..2328050 + 72 WP_223200558.1 hypothetical protein -
OS089_RS11355 (2328238) 2328238..2329785 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS089_RS11360 (2329971) 2329971..2330438 + 468 WP_000153338.1 SRPBCC domain-containing protein -
OS089_RS11365 (2330525) 2330525..2330707 + 183 WP_000079140.1 hypothetical protein -
OS089_RS11370 (2330911) 2330911..2331735 + 825 WP_000594633.1 formate/nitrite transporter family protein -
OS089_RS11375 (2332148) 2332148..2332684 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T265317 WP_000113263.1 NZ_CP113049:2327678-2327944 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265317 WP_000584499.1 NZ_CP113049:2327427-2327678 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References