265311

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 54736..55074 Replicon chromosome
Accession NZ_CP113049
Organism Staphylococcus aureus strain Ahri

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OS089_RS00395 Protein ID WP_011447039.1
Coordinates 54736..54912 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 54900..55074 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS089_RS00375 52422..52574 + 153 WP_000654329.1 hypothetical protein -
OS089_RS00380 52621..52909 + 289 Protein_75 hypothetical protein -
OS089_RS00385 52965..53339 + 375 WP_000340977.1 hypothetical protein -
OS089_RS00390 53760..54533 + 774 WP_025174055.1 staphylococcal enterotoxin type P -
OS089_RS00395 54736..54912 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 54900..55074 - 175 - - Antitoxin
OS089_RS00405 55124..55378 + 255 WP_000611512.1 phage holin -
OS089_RS00410 55390..56145 + 756 WP_000861038.1 CHAP domain-containing protein -
OS089_RS00415 56336..56827 + 492 WP_000920038.1 staphylokinase -
OS089_RS00420 57478..57813 + 336 Protein_83 SH3 domain-containing protein -
OS089_RS00425 58324..58674 + 351 WP_000702263.1 complement inhibitor SCIN-A -
OS089_RS00430 58727..58987 - 261 WP_001791826.1 hypothetical protein -
OS089_RS00435 59298..59477 - 180 WP_000669791.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - see / sak / scn 119..61544 61425
- inside Prophage - see / sak / scn / hysA 119..71341 71222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T265311 WP_011447039.1 NZ_CP113049:54736-54912 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT265311 NZ_CP113049:c55074-54900 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References