Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 765945..766468 Replicon chromosome
Accession NZ_CP113047
Organism Staphylococcus aureus strain Sett

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag OS087_RS04130 Protein ID WP_000074046.1
Coordinates 765945..766211 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2K4AGF2
Locus tag OS087_RS04135 Protein ID WP_000587615.1
Coordinates 766211..766468 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS087_RS04110 (761344) 761344..762528 - 1185 WP_000115415.1 MFS transporter -
OS087_RS04115 (762880) 762880..763653 - 774 WP_000072148.1 iron export ABC transporter permease subunit FetB -
OS087_RS04120 (763646) 763646..764308 - 663 WP_000923528.1 ATP-binding cassette domain-containing protein -
OS087_RS04125 (764556) 764556..765632 - 1077 WP_001076667.1 M42 family metallopeptidase -
OS087_RS04130 (765945) 765945..766211 - 267 WP_000074046.1 Txe/YoeB family addiction module toxin Toxin
OS087_RS04135 (766211) 766211..766468 - 258 WP_000587615.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS087_RS04140 (766826) 766826..767290 + 465 WP_000736689.1 DUF1307 domain-containing protein -
OS087_RS04145 (767440) 767440..769017 - 1578 WP_267830533.1 FMN-binding glutamate synthase family protein -
OS087_RS04150 (769207) 769207..769956 + 750 WP_049311723.1 CPBP family lipoprotein N-acylation protein LnsB -
OS087_RS04155 (770180) 770180..771373 - 1194 WP_000675403.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10658.27 Da        Isoelectric Point: 10.1384

>T265309 WP_000074046.1 NZ_CP113047:c766211-765945 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9746.68 Da        Isoelectric Point: 4.1111

>AT265309 WP_000587615.1 NZ_CP113047:c766468-766211 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AGF2

References