265307

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 709678..710195 Replicon chromosome
Accession NZ_CP113047
Organism Staphylococcus aureus strain Sett

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS087_RS03865 Protein ID WP_000113262.1
Coordinates 709678..709944 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS087_RS03870 Protein ID WP_000584499.1
Coordinates 709944..710195 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS087_RS03835 (705104) 705104..705640 - 537 WP_267830526.1 GNAT family N-acetyltransferase -
OS087_RS03840 (705873) 705873..706697 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS087_RS03845 (706914) 706914..707096 - 183 WP_000230294.1 hypothetical protein -
OS087_RS03850 (707180) 707180..707647 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS087_RS03855 (707833) 707833..709383 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS087_RS03860 (709572) 709572..709643 - 72 Protein_718 hypothetical protein -
OS087_RS03865 (709678) 709678..709944 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS087_RS03870 (709944) 709944..710195 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS087_RS03875 (710360) 710360..710461 - 102 WP_001791744.1 hypothetical protein -
OS087_RS03880 (710468) 710468..711067 - 600 WP_000162813.1 DsbA family protein -
OS087_RS03885 (711086) 711086..711448 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS087_RS03890 (711703) 711703..712953 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS087_RS03895 (713050) 713050..713781 - 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
OS087_RS03900 (713778) 713778..714497 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265307 WP_000113262.1 NZ_CP113047:c709944-709678 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265307 WP_000584499.1 NZ_CP113047:c710195-709944 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References