Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 588795..589318 Replicon chromosome
Accession NZ_CP113044
Organism Staphylococcus aureus strain LeBlanc

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS085_RS03165 Protein ID WP_000074048.1
Coordinates 588795..589061 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS085_RS03170 Protein ID WP_000587616.1
Coordinates 589061..589318 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS085_RS03145 (584102) 584102..585289 - 1188 WP_000026194.1 MFS transporter -
OS085_RS03150 (585685) 585685..586461 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS085_RS03155 (586454) 586454..587116 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS085_RS03160 (587364) 587364..588440 - 1077 WP_001076671.1 M42 family metallopeptidase -
OS085_RS03165 (588795) 588795..589061 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS085_RS03170 (589061) 589061..589318 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS085_RS03175 (589677) 589677..590132 + 456 WP_000732082.1 DUF1307 domain-containing protein -
OS085_RS03180 (590300) 590300..591877 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS085_RS03185 (592072) 592072..592821 + 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
OS085_RS03190 (593045) 593045..594238 - 1194 WP_267836561.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265293 WP_000074048.1 NZ_CP113044:c589061-588795 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265293 WP_000587616.1 NZ_CP113044:c589318-589061 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References