Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 531947..532464 Replicon chromosome
Accession NZ_CP113044
Organism Staphylococcus aureus strain LeBlanc

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS085_RS02890 Protein ID WP_000113262.1
Coordinates 531947..532213 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag OS085_RS02895 Protein ID WP_000584502.1
Coordinates 532213..532464 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS085_RS02860 (527373) 527373..527909 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS085_RS02865 (528142) 528142..528966 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS085_RS02870 (529183) 529183..529365 - 183 WP_000230294.1 hypothetical protein -
OS085_RS02875 (529449) 529449..529916 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS085_RS02880 (530102) 530102..531652 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS085_RS02885 (531841) 531841..531912 - 72 Protein_557 hypothetical protein -
OS085_RS02890 (531947) 531947..532213 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS085_RS02895 (532213) 532213..532464 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS085_RS02900 (532629) 532629..532730 - 102 WP_001791744.1 hypothetical protein -
OS085_RS02905 (532737) 532737..533336 - 600 WP_000162813.1 DsbA family protein -
OS085_RS02910 (533355) 533355..533714 - 360 WP_000819847.1 DUF4467 domain-containing protein -
OS085_RS02915 (533969) 533969..535219 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS085_RS02920 (535316) 535316..536047 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS085_RS02925 (536044) 536044..536763 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265291 WP_000113262.1 NZ_CP113044:c532213-531947 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT265291 WP_000584502.1 NZ_CP113044:c532464-532213 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References