Detailed information of TA system TA265285

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 92571..92870
• Replicon: chromosome
• Accession: NZ_CP113044
• Organism: Staphylococcus aureus strain LeBlanc

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: OS085_RS00505
• Protein ID: WP_011447039.1
• Coordinates: 92694..92870 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	92571..92626 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS085_RS00465	87902..88162	+	261	WP_001791826.1	hypothetical protein	-
OS085_RS00470	88215..88565	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
OS085_RS00475	89250..89699	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
OS085_RS00480	89794..90129	-	336	Protein_90	SH3 domain-containing protein	-
OS085_RS00485	90779..91270	-	492	WP_000919350.1	staphylokinase	-
OS085_RS00490	91461..92216	-	756	WP_000861038.1	CHAP domain-containing protein	-
OS085_RS00495	92228..92482	-	255	WP_000611512.1	phage holin	-
OS085_RS00500	92534..92641	+	108	WP_001791821.1	hypothetical protein	-
-	92563..92702	+	140	NuclAT_0	-	-
-	92563..92702	+	140	NuclAT_0	-	-
-	92563..92702	+	140	NuclAT_0	-	-
-	92563..92702	+	140	NuclAT_0	-	-
-	92571..92626	+	56	-	-	Antitoxin
OS085_RS00505	92694..92870	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
OS085_RS00510	93020..93316	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
OS085_RS00515	93374..93661	-	288	WP_001040261.1	hypothetical protein	-
OS085_RS00520	93708..93860	-	153	WP_001153681.1	hypothetical protein	-
OS085_RS00525	93850..97635	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	88215..144163	55948

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T265285 WP_011447039.1 NZ_CP113044:c92870-92694 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT265285 NZ_CP113044:92571-92626 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin