Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 92572..92871 Replicon chromosome
Accession NZ_CP113042
Organism Staphylococcus aureus strain Seraphine

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OS079_RS00505 Protein ID WP_011447039.1
Coordinates 92695..92871 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 92572..92627 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS079_RS00465 87903..88163 + 261 WP_001791826.1 hypothetical protein -
OS079_RS00470 88216..88566 - 351 WP_000702263.1 complement inhibitor SCIN-A -
OS079_RS00475 89251..89700 + 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
OS079_RS00480 89795..90130 - 336 Protein_90 SH3 domain-containing protein -
OS079_RS00485 90780..91271 - 492 WP_267837936.1 staphylokinase -
OS079_RS00490 91462..92217 - 756 WP_000861038.1 CHAP domain-containing protein -
OS079_RS00495 92229..92483 - 255 WP_000611512.1 phage holin -
OS079_RS00500 92535..92642 + 108 WP_001791821.1 hypothetical protein -
- 92564..92703 + 140 NuclAT_0 - -
- 92564..92703 + 140 NuclAT_0 - -
- 92564..92703 + 140 NuclAT_0 - -
- 92564..92703 + 140 NuclAT_0 - -
- 92572..92627 + 56 - - Antitoxin
OS079_RS00505 92695..92871 - 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
OS079_RS00510 93021..93317 - 297 WP_000539688.1 DUF2951 domain-containing protein -
OS079_RS00515 93375..93662 - 288 WP_001040261.1 hypothetical protein -
OS079_RS00520 93709..93861 - 153 WP_001153681.1 hypothetical protein -
OS079_RS00525 93851..97636 - 3786 WP_000582165.1 phage tail spike protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 88216..144164 55948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T265271 WP_011447039.1 NZ_CP113042:c92871-92695 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 56 bp

>AT265271 NZ_CP113042:92572-92627 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References