265264

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 781103..781620 Replicon chromosome
Accession NZ_CP113039
Organism Staphylococcus aureus strain Gwen

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag OS086_RS04220 Protein ID WP_000113265.1
Coordinates 781103..781369 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS086_RS04225 Protein ID WP_000584499.1
Coordinates 781369..781620 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS086_RS04190 (776531) 776531..777067 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS086_RS04195 (777301) 777301..778125 - 825 Protein_787 formate/nitrite transporter family protein -
OS086_RS04200 (778342) 778342..778524 - 183 WP_000230292.1 hypothetical protein -
OS086_RS04205 (778608) 778608..779075 - 468 WP_000153347.1 SRPBCC domain-containing protein -
OS086_RS04210 (779261) 779261..780808 - 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS086_RS04215 (780997) 780997..781068 - 72 Protein_791 hypothetical protein -
OS086_RS04220 (781103) 781103..781369 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
OS086_RS04225 (781369) 781369..781620 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS086_RS04230 (781785) 781785..781865 - 81 WP_223197974.1 hypothetical protein -
OS086_RS04235 (781893) 781893..782492 - 600 WP_000162810.1 DsbA family protein -
OS086_RS04240 (782511) 782511..782873 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS086_RS04245 (783128) 783128..784378 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
OS086_RS04250 (784475) 784475..785206 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS086_RS04255 (785203) 785203..785922 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T265264 WP_000113265.1 NZ_CP113039:c781369-781103 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265264 WP_000584499.1 NZ_CP113039:c781620-781369 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References