Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 768594..769111 Replicon chromosome
Accession NZ_CP113037
Organism Staphylococcus aureus strain Zilean

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag OS091_RS03905 Protein ID WP_000113263.1
Coordinates 768845..769111 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS091_RS03900 Protein ID WP_000584499.1
Coordinates 768594..768845 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS091_RS03870 764294..765013 + 720 WP_000479576.1 amino acid ABC transporter permease -
OS091_RS03875 765010..765741 + 732 WP_149569703.1 amino acid ABC transporter ATP-binding protein -
OS091_RS03880 765838..767088 - 1251 WP_001012236.1 FemA/FemB family glycyltransferase FmhA -
OS091_RS03885 767343..767705 + 363 WP_000819839.1 DUF4467 domain-containing protein -
OS091_RS03890 767724..768323 + 600 WP_000162810.1 DsbA family protein -
OS091_RS03895 768330..768421 + 92 Protein_701 hypothetical protein -
OS091_RS03900 768594..768845 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS091_RS03905 768845..769111 + 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
OS091_RS03910 769146..769217 + 72 WP_223200558.1 hypothetical protein -
OS091_RS03915 769405..770952 + 1548 WP_000727757.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS091_RS03920 771138..771605 + 468 WP_000153338.1 SRPBCC domain-containing protein -
OS091_RS03925 771692..771874 + 183 WP_000079140.1 hypothetical protein -
OS091_RS03930 772078..772902 + 825 WP_000594633.1 formate/nitrite transporter family protein -
OS091_RS03935 773315..773851 + 537 WP_000185901.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T265243 WP_000113263.1 NZ_CP113037:768845-769111 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265243 WP_000584499.1 NZ_CP113037:768594-768845 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References