265240

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2638392..2638915 Replicon chromosome
Accession NZ_CP113032
Organism Staphylococcus aureus strain Akali

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS080_RS13775 Protein ID WP_000074048.1
Coordinates 2638392..2638658 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS080_RS13780 Protein ID WP_000587616.1
Coordinates 2638658..2638915 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS080_RS13755 (2633699) 2633699..2634886 - 1188 WP_000026194.1 MFS transporter -
OS080_RS13760 (2635282) 2635282..2636058 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS080_RS13765 (2636051) 2636051..2636713 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS080_RS13770 (2636961) 2636961..2638037 - 1077 WP_001076671.1 M42 family metallopeptidase -
OS080_RS13775 (2638392) 2638392..2638658 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS080_RS13780 (2638658) 2638658..2638915 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS080_RS13785 (2639021) 2639021..2639215 - 195 WP_001790145.1 hypothetical protein -
OS080_RS13790 (2639274) 2639274..2639729 + 456 WP_000732080.1 DUF1307 domain-containing protein -
OS080_RS13795 (2639897) 2639897..2641474 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS080_RS13800 (2641669) 2641669..2642418 + 750 WP_267841474.1 CPBP family lipoprotein N-acylation protein LnsB -
OS080_RS13805 (2642642) 2642642..2643835 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265240 WP_000074048.1 NZ_CP113032:c2638658-2638392 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265240 WP_000587616.1 NZ_CP113032:c2638915-2638658 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References