265238

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2581540..2582057 Replicon chromosome
Accession NZ_CP113032
Organism Staphylococcus aureus strain Akali

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS080_RS13500 Protein ID WP_000113262.1
Coordinates 2581540..2581806 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS080_RS13505 Protein ID WP_000584499.1
Coordinates 2581806..2582057 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS080_RS13470 (2576966) 2576966..2577502 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS080_RS13475 (2577735) 2577735..2578559 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS080_RS13480 (2578776) 2578776..2578958 - 183 WP_000230294.1 hypothetical protein -
OS080_RS13485 (2579042) 2579042..2579509 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS080_RS13490 (2579695) 2579695..2581245 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS080_RS13495 (2581434) 2581434..2581505 - 72 Protein_2592 hypothetical protein -
OS080_RS13500 (2581540) 2581540..2581806 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS080_RS13505 (2581806) 2581806..2582057 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS080_RS13510 (2582222) 2582222..2582323 - 102 WP_001791744.1 hypothetical protein -
OS080_RS13515 (2582330) 2582330..2582929 - 600 WP_000162813.1 DsbA family protein -
OS080_RS13520 (2582948) 2582948..2583310 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS080_RS13525 (2583565) 2583565..2584815 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS080_RS13530 (2584912) 2584912..2585643 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS080_RS13535 (2585640) 2585640..2586359 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265238 WP_000113262.1 NZ_CP113032:c2581806-2581540 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265238 WP_000584499.1 NZ_CP113032:c2582057-2581806 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References