Detailed information of TA system TA265229

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2069624..2069923
• Replicon: chromosome
• Accession: NZ_CP113032
• Organism: Staphylococcus aureus strain Akali

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: OS080_RS10570
• Protein ID: WP_072482930.1
• Coordinates: 2069747..2069923 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2069624..2069679 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS080_RS10530	2065182..2065361	+	180	WP_000669789.1	hypothetical protein	-
OS080_RS10535	2065672..2065932	+	261	WP_001791826.1	hypothetical protein	-
OS080_RS10540	2065985..2066335	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
OS080_RS10545	2066845..2067180	-	336	Protein_2016	SH3 domain-containing protein	-
OS080_RS10550	2067832..2068323	-	492	WP_000920041.1	staphylokinase	-
OS080_RS10555	2068514..2069269	-	756	WP_000861038.1	CHAP domain-containing protein	-
OS080_RS10560	2069281..2069535	-	255	WP_000611512.1	phage holin	-
OS080_RS10565	2069587..2069694	+	108	Protein_2020	hypothetical protein	-
-	2069616..2069755	+	140	NuclAT_0	-	-
-	2069616..2069755	+	140	NuclAT_0	-	-
-	2069616..2069755	+	140	NuclAT_0	-	-
-	2069616..2069755	+	140	NuclAT_0	-	-
-	2069624..2069679	+	56	-	-	Antitoxin
OS080_RS10570	2069747..2069923	-	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
OS080_RS10575	2070032..2070805	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
OS080_RS10580	2071178..2071552	-	375	WP_000340977.1	hypothetical protein	-
OS080_RS10585	2071608..2071895	-	288	WP_001262621.1	hypothetical protein	-
OS080_RS10590	2071941..2072093	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2065985..2123511	57526

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T265229 WP_072482930.1 NZ_CP113032:c2069923-2069747 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT265229 NZ_CP113032:2069624-2069679 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin