Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 1299798..1300136 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag OS075_RS06665 Protein ID WP_011447039.1
Coordinates 1299798..1299974 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 1299962..1300136 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS075_RS06645 1295033..1298818 + 3786 WP_000582165.1 phage tail spike protein -
OS075_RS06650 1298808..1298960 + 153 WP_001153681.1 hypothetical protein -
OS075_RS06655 1299007..1299294 + 288 WP_001040261.1 hypothetical protein -
OS075_RS06660 1299352..1299648 + 297 WP_000539688.1 DUF2951 domain-containing protein -
OS075_RS06665 1299798..1299974 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 1299962..1300136 - 175 - - Antitoxin
OS075_RS06675 1300186..1300440 + 255 WP_000611512.1 phage holin -
OS075_RS06680 1300452..1301207 + 756 WP_000861038.1 CHAP domain-containing protein -
OS075_RS06685 1301398..1301889 + 492 WP_000919350.1 staphylokinase -
OS075_RS06690 1302539..1302874 + 336 Protein_1283 SH3 domain-containing protein -
OS075_RS06695 1302969..1303418 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
OS075_RS06700 1304103..1304453 + 351 WP_000702263.1 complement inhibitor SCIN-A -
OS075_RS06705 1304506..1304766 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb / sak / chp / scn 1248505..1304453 55948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T265217 WP_011447039.1 NZ_CP113029:1299798-1299974 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT265217 NZ_CP113029:c1300136-1299962 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References