Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 860204..860721 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS075_RS04280 Protein ID WP_000113262.1
Coordinates 860455..860721 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag OS075_RS04275 Protein ID WP_000584502.1
Coordinates 860204..860455 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS075_RS04245 (855905) 855905..856624 + 720 WP_000479576.1 amino acid ABC transporter permease -
OS075_RS04250 (856621) 856621..857352 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS075_RS04255 (857449) 857449..858699 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS075_RS04260 (858954) 858954..859313 + 360 WP_000819847.1 DUF4467 domain-containing protein -
OS075_RS04265 (859332) 859332..859931 + 600 WP_000162813.1 DsbA family protein -
OS075_RS04270 (859938) 859938..860039 + 102 WP_001791744.1 hypothetical protein -
OS075_RS04275 (860204) 860204..860455 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS075_RS04280 (860455) 860455..860721 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS075_RS04285 (860756) 860756..860827 + 72 Protein_816 hypothetical protein -
OS075_RS04290 (861016) 861016..862566 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS075_RS04295 (862752) 862752..863219 + 468 WP_000153344.1 SRPBCC domain-containing protein -
OS075_RS04300 (863303) 863303..863485 + 183 WP_000230294.1 hypothetical protein -
OS075_RS04305 (863702) 863702..864526 + 825 WP_000572040.1 formate/nitrite transporter family protein -
OS075_RS04310 (864759) 864759..865295 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265211 WP_000113262.1 NZ_CP113029:860455-860721 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT265211 WP_000584502.1 NZ_CP113029:860204-860455 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References