Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 803350..803873 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS075_RS04005 Protein ID WP_000074048.1
Coordinates 803607..803873 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS075_RS04000 Protein ID WP_000587616.1
Coordinates 803350..803607 (+) Length 86 a.a.

Genomic Context


OS075_RS03975OS075_RS03985OS075_RS03995OS075_RS04000OS075_RS04005OS075_RS04010OS075_RS04015OS075_RS04020OS075_RS04025OS075_RS03980OS075_RS03990
Location: 798430..799623 (1194 bp)
Type: Others
Protein ID: WP_000675401.1
Location: 800791..802368 (1578 bp)
Type: Others
Protein ID: WP_000143503.1
Location: 803050..803244 (195 bp)
Type: Others
Protein ID: WP_001790145.1
Location: 803350..803607 (258 bp)
Type: Antitoxin
Protein ID: WP_000587616.1
Location: 803607..803873 (267 bp)
Type: Toxin
Protein ID: WP_000074048.1
Location: 804228..805304 (1077 bp)
Type: Others
Protein ID: WP_001076671.1
Location: 805552..806214 (663 bp)
Type: Others
Protein ID: WP_000923520.1
Location: 806207..806983 (777 bp)
Type: Others
Protein ID: WP_000072147.1
Location: 807379..808566 (1188 bp)
Type: Others
Protein ID: WP_000026194.1
Location: 799847..800596 (750 bp)
Type: Others
Protein ID: WP_000072444.1
Location: 802536..802991 (456 bp)
Type: Others
Protein ID: WP_000732082.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OS075_RS03975 (798430)798430..799623+1194WP_000675401.1MFS transporter-
OS075_RS03980 (799847)799847..800596-750WP_000072444.1CPBP family lipoprotein N-acylation protein LnsB-
OS075_RS03985 (800791)800791..802368+1578WP_000143503.1FMN-binding glutamate synthase family protein-
OS075_RS03990 (802536)802536..802991-456WP_000732082.1DUF1307 domain-containing protein-
OS075_RS03995 (803050)803050..803244+195WP_001790145.1hypothetical protein-
OS075_RS04000 (803350)803350..803607+258WP_000587616.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
OS075_RS04005 (803607)803607..803873+267WP_000074048.1Txe/YoeB family addiction module toxinToxin
OS075_RS04010 (804228)804228..805304+1077WP_001076671.1M42 family metallopeptidase-
OS075_RS04015 (805552)805552..806214+663WP_000923520.1ATP-binding cassette domain-containing protein-
OS075_RS04020 (806207)806207..806983+777WP_000072147.1iron export ABC transporter permease subunit FetB-
OS075_RS04025 (807379)807379..808566+1188WP_000026194.1MFS transporter-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265209 WP_000074048.1 NZ_CP113029:803607-803873 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp


Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265209 WP_000587616.1 NZ_CP113029:803350-803607 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
PDB7V6W
PDB7V5Y
PDB7V5Z


Antitoxin

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Source
ID
Structure
PDB7V6W
PDB7V5Z
PDB7V5Y
AlphaFold DBW8TQT5

References