Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 803350..803873 Replicon chromosome
Accession NZ_CP113029
Organism Staphylococcus aureus strain Zoe

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS075_RS04005 Protein ID WP_000074048.1
Coordinates 803607..803873 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS075_RS04000 Protein ID WP_000587616.1
Coordinates 803350..803607 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS075_RS03975 (798430) 798430..799623 + 1194 WP_000675401.1 MFS transporter -
OS075_RS03980 (799847) 799847..800596 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
OS075_RS03985 (800791) 800791..802368 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS075_RS03990 (802536) 802536..802991 - 456 WP_000732082.1 DUF1307 domain-containing protein -
OS075_RS03995 (803050) 803050..803244 + 195 WP_001790145.1 hypothetical protein -
OS075_RS04000 (803350) 803350..803607 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS075_RS04005 (803607) 803607..803873 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS075_RS04010 (804228) 804228..805304 + 1077 WP_001076671.1 M42 family metallopeptidase -
OS075_RS04015 (805552) 805552..806214 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS075_RS04020 (806207) 806207..806983 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS075_RS04025 (807379) 807379..808566 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265209 WP_000074048.1 NZ_CP113029:803607-803873 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265209 WP_000587616.1 NZ_CP113029:803350-803607 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References