Detailed information of TA system TA265194

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1114974..1115553
• Replicon: chromosome
• Accession: NZ_CP113027
• Organism: Staphylococcus aureus strain Syndra

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OS083_RS05765
• Protein ID: WP_001025401.1
• Coordinates: 1114974..1115219 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1115188..1115553 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS083_RS05715 (1110732)	1110732..1111346	+	615	WP_000191466.1	hypothetical protein	-
OS083_RS05720 (1111343)	1111343..1111489	-	147	WP_001794606.1	hypothetical protein	-
OS083_RS05725 (1111526)	1111526..1111708	-	183	WP_000705240.1	hypothetical protein	-
OS083_RS05730 (1111804)	1111804..1112724	-	921	WP_000348133.1	exonuclease domain-containing protein	-
OS083_RS05735 (1112740)	1112740..1113354	-	615	WP_000801423.1	XRE family transcriptional regulator	-
OS083_RS05740 (1113526)	1113526..1113753	+	228	WP_001030311.1	hypothetical protein	-
OS083_RS05745 (1113779)	1113779..1114334	+	556	Protein_1057	phage antirepressor KilAC domain-containing protein	-
OS083_RS05750 (1114351)	1114351..1114545	+	195	WP_001148857.1	hypothetical protein	-
OS083_RS05755 (1114576)	1114576..1114719	+	144	WP_000939498.1	hypothetical protein	-
OS083_RS05760 (1114709)	1114709..1114918	-	210	WP_000642492.1	hypothetical protein	-
OS083_RS05765 (1114974)	1114974..1115219	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OS083_RS05770 (1115188)	1115188..1115553	-	366	WP_001128433.1	hypothetical protein	Antitoxin
OS083_RS05775 (1115608)	1115608..1115823	+	216	WP_001097552.1	hypothetical protein	-
OS083_RS05780 (1115848)	1115848..1116111	+	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
OS083_RS05785 (1116123)	1116123..1116284	+	162	WP_015986189.1	DUF1270 family protein	-
OS083_RS05790 (1116363)	1116363..1116686	+	324	WP_000174995.1	hypothetical protein	-
OS083_RS05795 (1116701)	1116701..1117063	+	363	WP_000279445.1	hypothetical protein	-
OS083_RS05800 (1117060)	1117060..1118226	+	1167	WP_000762525.1	DUF2800 domain-containing protein	-
OS083_RS05805 (1118252)	1118252..1118809	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T265194 WP_001025401.1 NZ_CP113027:1114974-1115219 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT265194 NZ_CP113027:c1115553-1115188 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin