265177

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 760130..760647 Replicon chromosome
Accession NZ_CP113018
Organism Staphylococcus aureus strain Taliyah

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS090_RS03760 Protein ID WP_000113262.1
Coordinates 760381..760647 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS090_RS03755 Protein ID WP_000584499.1
Coordinates 760130..760381 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS090_RS03725 (755828) 755828..756547 + 720 WP_000479576.1 amino acid ABC transporter permease -
OS090_RS03730 (756544) 756544..757275 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS090_RS03735 (757372) 757372..758622 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS090_RS03740 (758877) 758877..759239 + 363 WP_000819843.1 DUF4467 domain-containing protein -
OS090_RS03745 (759258) 759258..759857 + 600 WP_000162813.1 DsbA family protein -
OS090_RS03750 (759864) 759864..759965 + 102 WP_001791744.1 hypothetical protein -
OS090_RS03755 (760130) 760130..760381 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS090_RS03760 (760381) 760381..760647 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS090_RS03765 (760682) 760682..760753 + 72 Protein_714 hypothetical protein -
OS090_RS03770 (760942) 760942..762492 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS090_RS03775 (762678) 762678..763145 + 468 WP_000153344.1 SRPBCC domain-containing protein -
OS090_RS03780 (763229) 763229..763411 + 183 WP_000230294.1 hypothetical protein -
OS090_RS03785 (763628) 763628..764452 + 825 WP_000572040.1 formate/nitrite transporter family protein -
OS090_RS03790 (764685) 764685..765221 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265177 WP_000113262.1 NZ_CP113018:760381-760647 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265177 WP_000584499.1 NZ_CP113018:760130-760381 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References