Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 703272..703795 Replicon chromosome
Accession NZ_CP113018
Organism Staphylococcus aureus strain Taliyah

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS090_RS03485 Protein ID WP_000074048.1
Coordinates 703529..703795 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS090_RS03480 Protein ID WP_000587616.1
Coordinates 703272..703529 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS090_RS03460 (698352) 698352..699545 + 1194 WP_000675401.1 MFS transporter -
OS090_RS03465 (699769) 699769..700518 - 750 WP_000072442.1 CPBP family lipoprotein N-acylation protein LnsB -
OS090_RS03470 (700713) 700713..702290 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS090_RS03475 (702458) 702458..702913 - 456 WP_000732080.1 DUF1307 domain-containing protein -
OS090_RS03480 (703272) 703272..703529 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS090_RS03485 (703529) 703529..703795 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS090_RS03490 (704150) 704150..705226 + 1077 WP_001076671.1 M42 family metallopeptidase -
OS090_RS03495 (705474) 705474..706136 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS090_RS03500 (706129) 706129..706905 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS090_RS03505 (707301) 707301..708488 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265175 WP_000074048.1 NZ_CP113018:703529-703795 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265175 WP_000587616.1 NZ_CP113018:703272-703529 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References