Detailed information of TA system TA265171

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1902351..1902930
• Replicon: chromosome
• Accession: NZ_CP113016
• Organism: Staphylococcus aureus strain Azir

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: OS077_RS09570
• Protein ID: WP_001025401.1
• Coordinates: 1902351..1902596 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1902565..1902930 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS077_RS09515	1897540..1898460	-	921	WP_000348133.1	exonuclease domain-containing protein	-
OS077_RS09520	1898476..1899090	-	615	WP_000801423.1	XRE family transcriptional regulator	-
OS077_RS09525	1899262..1899489	+	228	WP_001030311.1	hypothetical protein	-
OS077_RS09530	1899515..1899757	+	243	WP_233641832.1	hypothetical protein	-
OS077_RS09535	1899714..1900214	-	501	WP_094314222.1	hypothetical protein	-
OS077_RS09540	1900262..1901038	+	777	WP_094314223.1	phage antirepressor	-
OS077_RS09545	1901054..1901272	+	219	WP_001001383.1	hypothetical protein	-
OS077_RS09550	1901322..1901519	+	198	WP_094314224.1	hypothetical protein	-
OS077_RS09555	1901506..1901886	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
OS077_RS09560	1901953..1902096	+	144	WP_000939498.1	hypothetical protein	-
OS077_RS09565	1902086..1902295	-	210	WP_000642492.1	hypothetical protein	-
OS077_RS09570	1902351..1902596	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
OS077_RS09575	1902565..1902930	-	366	WP_001128433.1	hypothetical protein	Antitoxin
OS077_RS09580	1902985..1903200	+	216	WP_001097552.1	hypothetical protein	-
OS077_RS09585	1903227..1903490	+	264	WP_001124196.1	helix-turn-helix domain-containing protein	-
OS077_RS09590	1903503..1903664	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
OS077_RS09595	1903758..1904075	+	318	WP_094314225.1	hypothetical protein	-
OS077_RS09600	1904068..1904370	+	303	WP_000165363.1	DUF2482 family protein	-
OS077_RS09605	1904375..1904635	+	261	WP_031584888.1	DUF1108 family protein	-
OS077_RS09610	1904648..1905184	+	537	WP_001004336.1	host-nuclease inhibitor Gam family protein	-
OS077_RS09615	1905185..1905829	+	645	WP_267836634.1	ERF family protein	-
OS077_RS09620	1905833..1906258	+	426	WP_094314227.1	single-stranded DNA-binding protein	-
OS077_RS09625	1906269..1906820	+	552	WP_031927924.1	NUMOD4 domain-containing protein	-
OS077_RS09630	1906821..1907492	+	672	WP_094314228.1	putative HNHc nuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1895368..1941328	45960
	-	inside	Prophage	-	-	1895368..1948429	53061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T265171 WP_001025401.1 NZ_CP113016:1902351-1902596 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT265171 NZ_CP113016:c1902930-1902565 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin