265149

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 295962..296485 Replicon chromosome
Accession NZ_CP113015
Organism Staphylococcus aureus strain Zed

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS078_RS01740 Protein ID WP_000074048.1
Coordinates 295962..296228 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS078_RS01745 Protein ID WP_000587616.1
Coordinates 296228..296485 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS078_RS01720 (291269) 291269..292456 - 1188 WP_000026194.1 MFS transporter -
OS078_RS01725 (292852) 292852..293628 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS078_RS01730 (293621) 293621..294283 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS078_RS01735 (294531) 294531..295607 - 1077 WP_001076671.1 M42 family metallopeptidase -
OS078_RS01740 (295962) 295962..296228 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS078_RS01745 (296228) 296228..296485 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS078_RS01750 (296591) 296591..296785 - 195 WP_001790145.1 hypothetical protein -
OS078_RS01755 (296844) 296844..297299 + 456 WP_000732080.1 DUF1307 domain-containing protein -
OS078_RS01760 (297467) 297467..299044 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS078_RS01765 (299239) 299239..299988 + 750 WP_000072442.1 CPBP family lipoprotein N-acylation protein LnsB -
OS078_RS01770 (300212) 300212..301405 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265149 WP_000074048.1 NZ_CP113015:c296228-295962 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265149 WP_000587616.1 NZ_CP113015:c296485-296228 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References