Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 239110..239627 Replicon chromosome
Accession NZ_CP113015
Organism Staphylococcus aureus strain Zed

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS078_RS01465 Protein ID WP_000113262.1
Coordinates 239110..239376 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS078_RS01470 Protein ID WP_000584499.1
Coordinates 239376..239627 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS078_RS01435 (234536) 234536..235072 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS078_RS01440 (235305) 235305..236129 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS078_RS01445 (236346) 236346..236528 - 183 WP_000230294.1 hypothetical protein -
OS078_RS01450 (236612) 236612..237079 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS078_RS01455 (237265) 237265..238815 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS078_RS01460 (239004) 239004..239075 - 72 Protein_250 hypothetical protein -
OS078_RS01465 (239110) 239110..239376 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS078_RS01470 (239376) 239376..239627 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS078_RS01475 (239792) 239792..239893 - 102 WP_001791744.1 hypothetical protein -
OS078_RS01480 (239900) 239900..240499 - 600 WP_000162813.1 DsbA family protein -
OS078_RS01485 (240518) 240518..240880 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS078_RS01490 (241135) 241135..242385 + 1251 WP_267836469.1 FemA/FemB family glycyltransferase FmhA -
OS078_RS01495 (242482) 242482..243213 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS078_RS01500 (243210) 243210..243929 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265147 WP_000113262.1 NZ_CP113015:c239376-239110 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265147 WP_000584499.1 NZ_CP113015:c239627-239376 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References