Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2301352..2301875 Replicon chromosome
Accession NZ_CP113009
Organism Staphylococcus aureus strain Orianna

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS092_RS11975 Protein ID WP_000074048.1
Coordinates 2301352..2301618 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS092_RS11980 Protein ID WP_000587616.1
Coordinates 2301618..2301875 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS092_RS11955 (2296659) 2296659..2297846 - 1188 WP_000026194.1 MFS transporter -
OS092_RS11960 (2298242) 2298242..2299018 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS092_RS11965 (2299011) 2299011..2299673 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS092_RS11970 (2299921) 2299921..2300997 - 1077 WP_001076671.1 M42 family metallopeptidase -
OS092_RS11975 (2301352) 2301352..2301618 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS092_RS11980 (2301618) 2301618..2301875 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS092_RS11985 (2301981) 2301981..2302175 - 195 WP_001790145.1 hypothetical protein -
OS092_RS11990 (2302234) 2302234..2302689 + 456 WP_000732080.1 DUF1307 domain-containing protein -
OS092_RS11995 (2302857) 2302857..2304434 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS092_RS12000 (2304629) 2304629..2305378 + 750 WP_000072442.1 CPBP family lipoprotein N-acylation protein LnsB -
OS092_RS12005 (2305602) 2305602..2306795 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265146 WP_000074048.1 NZ_CP113009:c2301618-2301352 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265146 WP_000587616.1 NZ_CP113009:c2301875-2301618 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References