Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2244500..2245017 Replicon chromosome
Accession NZ_CP113009
Organism Staphylococcus aureus strain Orianna

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS092_RS11700 Protein ID WP_000113262.1
Coordinates 2244500..2244766 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS092_RS11705 Protein ID WP_000584499.1
Coordinates 2244766..2245017 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS092_RS11670 2239926..2240462 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS092_RS11675 2240695..2241519 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS092_RS11680 2241736..2241918 - 183 WP_000230294.1 hypothetical protein -
OS092_RS11685 2242002..2242469 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS092_RS11690 2242655..2244205 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS092_RS11695 2244394..2244465 - 72 Protein_2260 hypothetical protein -
OS092_RS11700 2244500..2244766 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS092_RS11705 2244766..2245017 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS092_RS11710 2245182..2245283 - 102 WP_001791744.1 hypothetical protein -
OS092_RS11715 2245290..2245889 - 600 WP_000162813.1 DsbA family protein -
OS092_RS11720 2245908..2246270 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS092_RS11725 2246525..2247775 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS092_RS11730 2247872..2248603 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS092_RS11735 2248600..2249319 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265144 WP_000113262.1 NZ_CP113009:c2244766-2244500 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265144 WP_000584499.1 NZ_CP113009:c2245017-2244766 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References