Detailed information of TA system TA265135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1731252..1731551
• Replicon: chromosome
• Accession: NZ_CP113009
• Organism: Staphylococcus aureus strain Orianna

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: OS092_RS08765
• Protein ID: WP_072482930.1
• Coordinates: 1731375..1731551 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1731252..1731307 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OS092_RS08725	1726810..1726989	+	180	WP_000669789.1	hypothetical protein	-
OS092_RS08730	1727300..1727560	+	261	WP_001791826.1	hypothetical protein	-
OS092_RS08735	1727613..1727963	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
OS092_RS08740	1728473..1728808	-	336	Protein_1683	SH3 domain-containing protein	-
OS092_RS08745	1729460..1729951	-	492	WP_000920041.1	staphylokinase	-
OS092_RS08750	1730142..1730897	-	756	WP_000861038.1	CHAP domain-containing protein	-
OS092_RS08755	1730909..1731163	-	255	WP_000611512.1	phage holin	-
OS092_RS08760	1731215..1731322	+	108	Protein_1687	hypothetical protein	-
-	1731244..1731383	+	140	NuclAT_0	-	-
-	1731244..1731383	+	140	NuclAT_0	-	-
-	1731244..1731383	+	140	NuclAT_0	-	-
-	1731244..1731383	+	140	NuclAT_0	-	-
-	1731252..1731307	+	56	-	-	Antitoxin
OS092_RS08765	1731375..1731551	-	177	WP_072482930.1	type I toxin-antitoxin system toxin PepG1	Toxin
OS092_RS08770	1731660..1732433	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
OS092_RS08775	1732806..1733180	-	375	WP_000340977.1	hypothetical protein	-
OS092_RS08780	1733236..1733523	-	288	WP_001262621.1	hypothetical protein	-
OS092_RS08785	1733569..1733721	-	153	WP_001000059.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	1727613..1785139	57526

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T265135 WP_072482930.1 NZ_CP113009:c1731551-1731375 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

Antitoxin

Nucleotide

• Length: 56 bp

>AT265135 NZ_CP113009:1731252-1731307 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin