Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 739037..739554 Replicon chromosome
Accession NZ_CP113007
Organism Staphylococcus aureus strain Ryze

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS082_RS03465 Protein ID WP_000113262.1
Coordinates 739288..739554 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS082_RS03460 Protein ID WP_000584499.1
Coordinates 739037..739288 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS082_RS03430 (734735) 734735..735454 + 720 WP_000479576.1 amino acid ABC transporter permease -
OS082_RS03435 (735451) 735451..736182 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS082_RS03440 (736279) 736279..737529 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS082_RS03445 (737784) 737784..738146 + 363 WP_000819843.1 DUF4467 domain-containing protein -
OS082_RS03450 (738165) 738165..738764 + 600 WP_000162813.1 DsbA family protein -
OS082_RS03455 (738771) 738771..738872 + 102 WP_001791744.1 hypothetical protein -
OS082_RS03460 (739037) 739037..739288 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS082_RS03465 (739288) 739288..739554 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS082_RS03470 (739589) 739589..739660 + 72 Protein_691 hypothetical protein -
OS082_RS03475 (739849) 739849..741399 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS082_RS03480 (741585) 741585..742052 + 468 WP_000153344.1 SRPBCC domain-containing protein -
OS082_RS03485 (742136) 742136..742318 + 183 WP_000230294.1 hypothetical protein -
OS082_RS03490 (742535) 742535..743359 + 825 WP_000572040.1 formate/nitrite transporter family protein -
OS082_RS03495 (743592) 743592..744128 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265116 WP_000113262.1 NZ_CP113007:739288-739554 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265116 WP_000584499.1 NZ_CP113007:739037-739288 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References