Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 682179..682702 Replicon chromosome
Accession NZ_CP113007
Organism Staphylococcus aureus strain Ryze

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag OS082_RS03190 Protein ID WP_000074048.1
Coordinates 682436..682702 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag OS082_RS03185 Protein ID WP_000587616.1
Coordinates 682179..682436 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS082_RS03165 (677259) 677259..678452 + 1194 WP_000675401.1 MFS transporter -
OS082_RS03170 (678676) 678676..679425 - 750 WP_000072442.1 CPBP family lipoprotein N-acylation protein LnsB -
OS082_RS03175 (679620) 679620..681197 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
OS082_RS03180 (681365) 681365..681820 - 456 WP_000732080.1 DUF1307 domain-containing protein -
OS082_RS03185 (682179) 682179..682436 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS082_RS03190 (682436) 682436..682702 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
OS082_RS03195 (683057) 683057..684133 + 1077 WP_001076671.1 M42 family metallopeptidase -
OS082_RS03200 (684381) 684381..685043 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
OS082_RS03205 (685036) 685036..685812 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
OS082_RS03210 (686208) 686208..687395 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T265114 WP_000074048.1 NZ_CP113007:682436-682702 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT265114 WP_000587616.1 NZ_CP113007:682179-682436 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References