Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2073157..2073674 Replicon chromosome
Accession NZ_CP113005
Organism Staphylococcus aureus strain Galio

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag OS073_RS11035 Protein ID WP_000113262.1
Coordinates 2073157..2073423 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag OS073_RS11040 Protein ID WP_000584499.1
Coordinates 2073423..2073674 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OS073_RS11005 (2068583) 2068583..2069119 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
OS073_RS11010 (2069352) 2069352..2070176 - 825 WP_000572040.1 formate/nitrite transporter family protein -
OS073_RS11015 (2070393) 2070393..2070575 - 183 WP_000230294.1 hypothetical protein -
OS073_RS11020 (2070659) 2070659..2071126 - 468 WP_000153344.1 SRPBCC domain-containing protein -
OS073_RS11025 (2071312) 2071312..2072862 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
OS073_RS11030 (2073051) 2073051..2073122 - 72 Protein_2082 hypothetical protein -
OS073_RS11035 (2073157) 2073157..2073423 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
OS073_RS11040 (2073423) 2073423..2073674 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OS073_RS11045 (2073839) 2073839..2073940 - 102 WP_001791744.1 hypothetical protein -
OS073_RS11050 (2073947) 2073947..2074546 - 600 WP_000162813.1 DsbA family protein -
OS073_RS11055 (2074565) 2074565..2074927 - 363 WP_000819843.1 DUF4467 domain-containing protein -
OS073_RS11060 (2075182) 2075182..2076432 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
OS073_RS11065 (2076529) 2076529..2077260 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
OS073_RS11070 (2077257) 2077257..2077976 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T265111 WP_000113262.1 NZ_CP113005:c2073423-2073157 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT265111 WP_000584499.1 NZ_CP113005:c2073674-2073423 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References