26509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1225635..1226169 Replicon plasmid pSINMEB02
Accession NC_017323
Organism Sinorhizobium meliloti BL225C

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag SINMEB_RS30665 Protein ID WP_017268214.1
Coordinates 1225635..1225931 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag SINMEB_RS30670 Protein ID WP_003527850.1
Coordinates 1225921..1226169 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINMEB_RS30640 1221110..1222489 - 1380 WP_027988292.1 sodium:alanine symporter family protein -
SINMEB_RS37750 1222722..1222865 - 144 WP_153318136.1 hypothetical protein -
SINMEB_RS30645 1223023..1223232 - 210 WP_003527838.1 dodecin family protein -
SINMEB_RS30650 1223522..1223968 + 447 WP_014527651.1 DNA-binding protein -
SINMEB_RS30655 1223972..1224157 - 186 WP_014527652.1 hypothetical protein -
SINMEB_RS30660 1224324..1224722 - 399 WP_010974988.1 hypothetical protein -
SINMEB_RS35555 1225296..1225556 + 261 Protein_1096 helix-turn-helix domain-containing protein -
SINMEB_RS30665 1225635..1225931 - 297 WP_017268214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SINMEB_RS30670 1225921..1226169 - 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SINMEB_RS30680 1226788..1226913 + 126 Protein_1099 IS481 family transposase -
SINMEB_RS30685 1226997..1227791 - 795 WP_014527654.1 methyltransferase domain-containing protein -
SINMEB_RS30690 1227795..1228595 - 801 WP_014527655.1 ABC transporter ATP-binding protein -
SINMEB_RS30695 1228592..1229635 - 1044 WP_010974980.1 iron ABC transporter permease -
SINMEB_RS30700 1229632..1230699 - 1068 WP_010974979.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1690594 1690594
- flank IS/Tn - - 1226722..1226913 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11490.20 Da        Isoelectric Point: 10.7543

>T26509 WP_017268214.1 NC_017323:c1225931-1225635 [Sinorhizobium meliloti BL225C]
MATERPFRLAPAAKADLRKIWRYKARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGSHIVYFRDRGD
RIDIIRILHGRMDAQRHL

Download         Length: 297 bp

>T26509 NC_017323:c1225931-1225635 [Sinorhizobium meliloti BL225C]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTGCCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACAAGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGCAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGACCGGGTTATCTCAAATACCCGGCAGGATCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGGATGGATGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT26509 WP_003527850.1 NC_017323:c1226169-1225921 [Sinorhizobium meliloti BL225C]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT26509 NC_017323:c1226169-1225921 [Sinorhizobium meliloti BL225C]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References