26508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 870823..871490 Replicon plasmid pSINMEB02
Accession NC_017323
Organism Sinorhizobium meliloti BL225C

Toxin (Protein)


Gene name vapC Uniprot ID A0A7X2CQG3
Locus tag SINMEB_RS28995 Protein ID WP_014527488.1
Coordinates 871047..871490 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92WE1
Locus tag SINMEB_RS28990 Protein ID WP_010975287.1
Coordinates 870823..871050 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SINMEB_RS28970 866217..867098 - 882 WP_014527484.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
SINMEB_RS28975 867216..868508 - 1293 WP_014527485.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
SINMEB_RS28980 868877..870166 + 1290 WP_014527486.1 SDR family oxidoreductase -
SINMEB_RS28985 870166..870639 + 474 WP_014527487.1 DUF2269 family protein -
SINMEB_RS28990 870823..871050 + 228 WP_010975287.1 hypothetical protein Antitoxin
SINMEB_RS28995 871047..871490 + 444 WP_014527488.1 PIN domain-containing protein Toxin
SINMEB_RS29000 871506..872444 - 939 WP_010975284.1 choline ABC transporter substrate-binding protein -
SINMEB_RS29005 872513..873343 - 831 WP_014527489.1 SDR family oxidoreductase -
SINMEB_RS29010 873340..873837 - 498 WP_010975282.1 acetone carboxylase subunit gamma -
SINMEB_RS29015 873841..876033 - 2193 WP_014527490.1 hydantoinase B/oxoprolinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1690594 1690594


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 15592.86 Da        Isoelectric Point: 6.6378

>T26508 WP_014527488.1 NC_017323:871047-871490 [Sinorhizobium meliloti BL225C]
VTFLLDVNVLIALIDPSHIGHDDAHEWFASIGQTAWATCPITENGVIRIVGNPEYPNSPGSPLPAMEIVAKLRSLPGHVF
WPDDVSLVGSSDIIPSKILTSGQVTDTYLLALAKARGGKLATFDRKLSAAAVTKGNSALHLIATNRS

Download         Length: 444 bp

>T26508 NC_017323:871047-871490 [Sinorhizobium meliloti BL225C]
GTGACTTTCCTGCTCGACGTCAATGTGCTGATTGCCTTGATCGATCCGAGCCATATAGGCCATGATGATGCGCACGAATG
GTTCGCGTCGATTGGTCAGACCGCGTGGGCCACCTGCCCAATTACCGAAAATGGTGTCATCCGGATCGTCGGCAATCCCG
AGTATCCCAATTCTCCCGGCTCACCGTTACCCGCGATGGAGATCGTCGCCAAATTGCGGTCGCTCCCCGGTCATGTTTTT
TGGCCGGACGATGTGAGCCTTGTCGGGTCAAGTGATATCATCCCATCGAAAATCCTGACTTCGGGGCAGGTGACTGACAC
CTATCTGCTTGCGCTCGCCAAGGCGCGTGGGGGCAAGCTGGCGACATTCGATCGCAAGCTGTCGGCAGCGGCGGTCACGA
AGGGCAATTCCGCCTTGCACCTGATCGCGACGAATAGGTCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8174.39 Da        Isoelectric Point: 9.1096

>AT26508 WP_010975287.1 NC_017323:870823-871050 [Sinorhizobium meliloti BL225C]
MRTTLAIDDDVLIAAKAMATQQQRSVGEVISELARRSLRRPRSGGERNGIPLLSPRPDAPPVTLEIVNALRDELA

Download         Length: 228 bp

>AT26508 NC_017323:870823-871050 [Sinorhizobium meliloti BL225C]
ATGAGAACGACCTTGGCTATTGACGACGATGTCCTGATCGCCGCAAAGGCAATGGCGACCCAACAGCAGCGGAGCGTCGG
CGAGGTAATTTCCGAACTGGCGAGGCGTTCTCTGCGCCGGCCGCGCAGCGGCGGCGAGCGTAATGGAATTCCTCTCCTGT
CGCCTCGTCCGGACGCACCGCCCGTGACGCTCGAGATCGTCAACGCCCTGCGTGACGAACTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X2CQG3

Antitoxin

Source ID Structure
AlphaFold DB Q92WE1

References